Brain hallucinogens: Tryptamines found in pineal gland

One of the strongest hallucinogenic drugs is N,N-dimethyltryptamine, known colloquially as DMT, which has a similar action to psilocybin but acts over a shorter time scale. So, it might come as a surprise that DMT and two related tryptamines also exist naturally in the human body, having been detected in blood, urine and cerebrospinal fluid.

No-one knows what DMT does or why it is there. Some scientists have speculated that it might have a link to psychosis but there is no proof to support that. The enzyme which produces DMT in the body, indole-N-methyltransferase, has been found in the pineal gland, in motor neurons in the spinal cord, and in the retina, but DMT has not, prolonging the mystery about its function.